Analysis of nutritional markers and correlation with outcomes in IBD
Research type
Research Study
Full title
Nutritional status and nutritional biomarkers and association with clinical outcomes in inflammatory bowel disease
IRAS ID
337108
Contact name
Shameer Mehta
Contact email
Sponsor organisation
Barts Health NHS Trust
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
Patients with inflammatory bowel disease (IBD) are at risk of malnutrition and also loss of muscle mass and function, which is a condition known as sarcopenia. It is important to identify if a patient has malnutrition and/or sarcopenia because this can impact on how a patient may respond to their medical treatment or on the success of their surgical treatment. It is also important because interventions such as oral nutritional supplements, intravenous nutrition and exercise, can be undertaken to improve this. There are several tools and assessment methods which exist to determine if patients are at risk of these problems, but we do not yet know which is the best one for patients with IBD. Some measures include weight, body mass index, blood tests, CT or MRI scans and tests such as grip strength. This study hopes to determine which tests are best at recognising undernutrition in IBD by comparing them and relating them to clinical outcomes, such as response to biologic therapy or development of post-operative complications. We also aim to show the scans that happen as part of routine assessment can be used feasibly to determine a muscle mass in patients with IBD. The study will help to provide us with an optimal tool, that can be used successfully and routinely in our clinical practice for our patients with IBD. Enrolment in this study will involve a detailed nutritional assessment, which will include weight, height and body measurements. It will also involve completing a questionnaire. This assessment will be performed a total of three times throughout the course of the study. There will be no additional blood tests, scans or hospital visits beyond what is needed for standard clinical care.
REC name
South West - Frenchay Research Ethics Committee
REC reference
24/SW/0064
Date of REC Opinion
20 May 2024
REC opinion
Favourable Opinion