Analysis of neurodegenerative disease-associated proteins
Research type
Research Study
Full title
Structural, biochemical and functional analyses of pathological protein assemblies in neurodegenerative diseases
IRAS ID
341393
Contact name
Benjamin Ryskeldi-Falcon
Contact email
Sponsor organisation
UK Research and Innovation (Medical Research Council is part of UKRI)
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
The abnormal assembly of specific proteins in the central nervous system leads to multiple neurodegenerative diseases. However, we do not understand why or how this abnormal protein assembly occurs, nor how it contributes to the development of neurodegenerative diseases. This understanding is required for the future development of effective diagnostic and therapeutic strategies for neurodegenerative diseases, which currently do not exist. This project will perform structural, biochemical and functional analyses of abnormal protein assemblies in postmortem and biopsy human tissue samples. These human tissue samples will be obtained from Research Tissue Banks and research collaborators. Currently, there are no accurate experimental models of abnormal protein assembly that could substitute for the use of human tissue samples. The results of this project will also inform the development of such experimental models for future studies. This project is funded by the UK Medical Research Council.
REC name
London - Chelsea Research Ethics Committee
REC reference
25/PR/0494
Date of REC Opinion
23 Apr 2025
REC opinion
Favourable Opinion