Analysis of molecular signalling regulating muscle insulin sensitivity
Research type
Research Study
Full title
An analysis of the molecular signalling mechanisms that regulate human muscle insulin sensitivity
IRAS ID
181933
Contact name
Ian Salt
Contact email
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
Insulin stimulates the storage of sugar (glucose) in muscle tissue, helping to reduce blood sugar and store energy after a meal. To do this, insulin increases the uptake of glucose by muscle. In people with type 2 diabetes, this process does not work properly as they are resistant to their insulin. The fundamental mechanisms by which this occurs are poorly understood. Our laboratory is interested in these fundamental mechanisms by which insulin acts, aiming to identify targets that may be useful for the development of new therapies for type 2 diabetes. The majority of our studies to study these targets utilise cells from rodents grown in the laboratory, but it is important to understand how these processes work in humans. In this study, we seek to use stored muscle tissue preparations from individuals in whom we have previously measured the sensitivity to insulin. We will measure the levels of proteins we have identified as having a potential role in the regulation of insulin action.
REC name
West Midlands - Solihull Research Ethics Committee
REC reference
15/WM/0186
Date of REC Opinion
14 May 2015
REC opinion
Favourable Opinion