Analysis of human tissue for prevention of cardiovascular events
Research type
Research Study
Full title
Analysis of human tissue for prevention of cardiovascular events
IRAS ID
255023
Contact name
May Azzawi
Contact email
Sponsor organisation
Manchester metropolitan university
Duration of Study in the UK
1 years, 11 months, 28 days
Research summary
Elevated blood pressure (hypertension) plays a major role in the development of cardiovascular disease (CVD) and is an important public health concern globally. It is often associated with inflammation, accompanied by decreased capacity of the blood vessels to dilate, mainly due to poor production of dilator mediators. The inflammation observed in hypertensive patients, likely underpins the poorly functioning cells within the blood vessels. Resveratrol (RV) is a natural plant product with suggested protective cardiovascular effects. Our aim is to test the effect of resveratrol, and its more potent synthetic derivatives, on isolated cells and blood vessels, to help restore dilator function and hence adequate blood supply into tissues to prevent damage (ischaemia).
We will obtain artery segments from 100 patients who will be undergoing coronary artery bypass grafting (CABG) and valve replacement surgery, and also the atrial appendage (removed as a common procedure during CABG). The tissues will be collected from the operating theatre at the time of surgery and cut into three sections, for histological analysis; for isolation of smooth muscle cells to be grown in tissue culture; and for functional contractile experimentation. We envisage obtaining all the necessary tissues within 1-2 years, given that the clinical team conduct approximately 40 of these operations per month.REC name
North West - Preston Research Ethics Committee
REC reference
20/NW/0098
Date of REC Opinion
5 May 2020
REC opinion
Further Information Favourable Opinion