Analysis of dementia patient blood samples
Research type
Research Study
Full title
Proteomic analysis of neural-derived exosomes isolated from plasma of people with Alzheimer’s disease, mild cognitive impairment and dementia with Lewy bodies : with focus upon potential clinical biomarkers
IRAS ID
279342
Contact name
Millie Sander
Contact email
Sponsor organisation
University of Exeter
Duration of Study in the UK
2 years, 7 months, 30 days
Research summary
The proposed study will isolate neural-derived exosomes (particles released by neural cells) from the blood of people with Alzheimer’s disease, dementia with Lewy bodies, individuals with mild cognitive impairment and controls. Disease-associated proteins such as tau, α-synuclein and β-amyloid will be quantified, and comparisons will be made between disease states and stages.
The results will be used to determine whether there are any significant differences in the proteins exhibited among these structures during disease pathogenesis and/or onset. Any differences between groups could indicate potential for the development of a blood-based diagnostic test for AD and/or DLB, and a potential blood based biomarker for clinical trials.REC name
London - Fulham Research Ethics Committee
REC reference
21/LO/0153
Date of REC Opinion
13 Apr 2021
REC opinion
Further Information Favourable Opinion