Anal Cancer Risk In Women
Research type
Research Study
Full title
The Role of Early Detection and Treatment of Anal Intraepithelial Neoplasia in the Prevention of Anal Squamous Cell Carcinoma in Women: Establishing the Disease Burden in Women with Genital Cancer
IRAS ID
315094
Contact name
Christos Kontovounisios
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
1 years, 7 months, 26 days
Research summary
Summary of Research:
We will be conducting a retrospective cross-sectional study involving the analysis of Cancer Registry Data. As part of this study, we will look at cancer registration data collated by the National Cancer Registration and Analysis Service (NCRAS; the national cancer registry in England), via NHS Digital data access request service (DARS), on all female patients aged between 25-90+ years in England with a registered diagnosis of anal and vaginal and/or vulvar and/or cervical cancer and/or high grade squamous intraepithelial lesions (HSIL) between 2001 and 2019. For these patients we will be looking at information on age at diagnosis, ethnicity, deprivation and performance status. We will also be looking at information on the stage of the cancer at diagnosis, the date of each diagnosis, the treatment received for the diagnosis and the route to diagnosis. Additionally, we will be requesting the total number of women/year (between 1995 and 2019), in England, aged between 25-90+ years with a diagnosis of anal, vulvar, vaginal and cervical cancer as well as their respective HSILs. Together this data will be used to establish the incidence of anal cancer and HSIL in women with genital cancers and/or HSILs, the progression timelines between the different pathologies, as well as identify relevant sociodemographic risk factors in this patient group.Summary of Results:
Anal cancer is more common in women with a background of genital precancerous and cancerous lesions. Despite this, very little research has focused on this high-risk population.
This study aims to investigate this population to better understand their risk factors for anal cancer and the relationships between genital and anal pathology. These findings add to the body of evidence demonstrating the risk of anal cancer in women who had cervical, vaginal or vulval pathology. They show that these women develop anal cancer at a younger age than women who have never had genital pathology and strengthen the argument to
consider anal cancer screening for these patients.REC name
London - Surrey Research Ethics Committee
REC reference
22/PR/0768
Date of REC Opinion
11 Jul 2022
REC opinion
Further Information Favourable Opinion