Anaesthetic technique and lung cancer outcomes
Research type
Research Study
Full title
Association between anaesthetic and analgesic techniques and cancer outcomes following surgical resection of lung cancer
IRAS ID
194712
Contact name
Ben Shelley
Contact email
Sponsor organisation
NWTC Board / Golden Jubilee Foundation
Duration of Study in the UK
0 years, 10 months, 31 days
Research summary
Background
Each year over 5000 patients undergo lung cancer surgery in the UK. Recent trends and current guidelines suggest this figure is set to increase. It is increasingly being understood that the anaesthetic and analgesic (pain relieving) techniques used at the time of all forms of cancer surgery can influence the immune system and have a long lasting effect in terms of cancer outcome. In some types of surgery (e.g. breast cancer surgery) certain techniques / drugs has been associated with increased risk of recurrence, metastasis and mortality; though this topic has been the subject of little study in patients undergoing lung cancer surgery.Aim
In this study we aim to use data already collected in two large databases to examine the effects of anaesthetic and analgesic techniques on cancer outcome.Expected outcome
Demonstration of a link between anaesthetic and analgesic techniques used at the time of surgery and cancer outcome by this study would require validation in a prospective randomised controlled trail. Clear evidence of a link would mean that clinicians would need to carefully consider a change in practice, avoiding drugs and techniques associated with poor outcomes; a change which ultimately should lead to an improvement in patient survival.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
16/EE/0056
Date of REC Opinion
9 Feb 2016
REC opinion
Favourable Opinion