An investigation of the mechanism of action of Seretide in COPD

• Research type

  Research Study

• Full title

  An investigation into the mechanisms of action of a combined long acting beta agonist/inhaled corticosteroid (Seretide 500 accuhaler) on the bacterial colonisation, immunology and inflammation of patients with Chronic Obstructive Pulmonary Disease (COPD)

• IRAS ID

  22376

• Contact name

  Simon Bourne

• Eudract number

  2009-015876-86

• Clinicaltrials.gov Identifier

  NCT00974805

• Research summary

  This study is investigating the possible mechanisms of action of an inhaled treatment (Seretide), currently used worldwide in millions of patients with COPD (Chronic Obstructive Pulmonary Disease) and how it improves the symptoms of these patients. Previous research has failed to identify the mechanisms at play other than dilation of the airways. The research community has long thought the mechanism to be immune based or anti inflammatory but despite intensive research this has not yet been identified.

• REC name

  South Central - Hampshire A Research Ethics Committee

• REC reference

  10/H0502/7

• Date of REC Opinion

  11 Mar 2010

• REC opinion

  Further Information Favourable Opinion