An investigation into the mechanisms of lung injury and repair.
Research type
Research Study
Full title
An investigation into the mechanisms of lung injury and repair in inflammatory, infective, fibrotic and destructive lung diseases.
IRAS ID
39531
Contact name
Joanna Porter
Contact email
Sponsor organisation
UCLH
Research summary
This research is aimed at understanding more about how the lung is able to recover from damage caused by infection, inhaled toxins (including cigarette smoke), inflammation and other diseases. We are examining many different biological process by which inflammatory cells and debris are removed from the lung and the lung tissues repairs itself so that it can function properly again. In many patients these repair processes appear to go wrong and the lungs become scarred and damaged. By examining the repair processes in normal lungs and comparing them with the processes in lungs that have become scarred we hope that we will be able to detect differences which will help with therapies in the future. In order to do this work we need to take small bits of lung from patients with normal lungs and patients with diseased lungs. These bits of lung can then be looked at in the laboratory to see how they repair after injury and the way in which they are able to clear inflammatory cells across them.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
13/LO/0900
Date of REC Opinion
9 Aug 2013
REC opinion
Further Information Favourable Opinion