An Investigation into the Mechanism of Inhalational Cough Challenge
Research type
Research Study
Full title
An Investigation into the Mechanism of Inhalational Cough Challenge
IRAS ID
164364
Contact name
Alyn Morice
Contact email
Sponsor organisation
Hull & East Yorkshire Hospitals NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 11 months, 27 days
Research summary
This study aims to further define the mechanism of cough. Despite its commonplace use in respiratory medicine, the mechanism whereby inhalational cough challenge with a variety of mild acid aerosols produces a dose related and predictable cough is unknown.
In this proposal we wish to use our established cough challenge methodology to explore the mechanism of action of agents provoking cough both in healthy volunteers, and patients with chronic cough.
By changing aspects of the standard cough challenge protocol we aim to test these hypotheses:
-Intracellular changes in pH, rather than extracellular changes, are key in the activation of TRP receptors, the main sensor for provoking cough.
-ATP (adenosine triphosphate) acting through P2X channels is the mechanism of increased nerve excitability underlying cough hypersensitivity.The greater understanding of the cough reflex which this study will yield could have important clinical applications pointing the way to novel therapeutic avenues, as well as enhancing our fundamental understanding of the genesis of cough
REC name
South East Scotland REC 02
REC reference
14/SS/1071
Date of REC Opinion
22 Oct 2014
REC opinion
Further Information Favourable Opinion