An integrated approach to investigate immunosenescence
Research type
Research Study
Full title
An integrated approach to dissect determinants, risk factors and pathways of ageing of the immune system
IRAS ID
188383
Contact name
Eoin McKinney
Contact email
Sponsor organisation
University of Cambridge
Duration of Study in the UK
4 years, 0 months, 0 days
Research summary
Changes occurring in the immune system of ageing humans – broadly referred to as ‘immunosenescence’ –have huge consequences on health, but the exact nature of these modifications and the underlying mechanisms are still largely unknown. We propose to define the extent to which immunosenescence comprises changes in levels of specific immune cell types or molecules, or functional competence of cells, and to detect genetic and non genetic factors that drive these changes. The studies are designed to understand better the mechanisms and pathways of immunosenescence in order to prevent or alleviate imbalances and resulting immunemediated pathological effects in
the immune system of the elderly.REC name
East of England - Essex Research Ethics Committee
REC reference
15/EE/0327
Date of REC Opinion
17 Sep 2015
REC opinion
Favourable Opinion