An exploratory study to establish a rhinovirus challenge model
Research type
Research Study
Full title
An exploratory study to establish a rhinovirus challenge model in asthma patients
IRAS ID
133001
Contact name
David Rogers
Contact email
Sponsor organisation
The Medicines Evaluation Unit (MEU)Ltd. (Investigator led study)
Research summary
This is an exploratory study to assess the effect of Rhinovirus (RV) challenge in patients with asthma. The study will be conducted in two phases: a pilot phase comprising the RV challenge only followed by a full recruitment phase comprising two cohorts, Cohort A which will consist of the RV challenge only and Cohort B in which a RV challenge combined with an allergen challenge will be performed. The purpose of the pilot phase is to ensure that the rhinovirus challenge in our hands leads to the expected symptoms and change in lung function in patients with asthma, before embarking on the main phase which involves more complexity including bronchoscopies. Cohort A will consist of asthma patients and healthy volunteers and Cohort B will be asthma patient only. The study will review lung function, symptoms and biological changes in the airways as well as safety. The best model will be used in future studies investigating the efficacy of novel investigational asthmatic drugs. We will also evaluate whether the allergic/eosinophilic phenotype has a different response to RV challenge
REC name
North West - Preston Research Ethics Committee
REC reference
14/NW/0121
Date of REC Opinion
7 Mar 2014
REC opinion
Favourable Opinion