AMICI study Version 1.0
Research type
Research Study
Full title
Acute Magnetic Resonance Imaging in Cerebral Ischaemia Study
IRAS ID
130485
Contact name
James Kennedy
Contact email
Sponsor organisation
University of Oxford
Research summary
A stroke is the loss of one or more brain functions when either a clot blocks a blood vessel supplying the brain or there is bleeding into the brain. Stroke affects thousands of people in the UK each year but there are very limited treatments available. We do not fully understand the disease processes that are occurring following stroke.
The aim of this study is to use novel magnetic resonance imaging (MRI) scanning techniques to investigate stroke patients in the period immediately following symptom onset. It is hoped that this will enable us to investigate the changes that occur in the early time period after a stroke which are most likely to be good targets for future treatments.
We will recruit patients with stroke who present to hospital within 24 hours of symptom onset. The research will be carried out in a purpose built research facility next to the Emergency Department in the John Radcliffe Hospital, Oxford. It is funded by the Oxford Biomedical Research Centre, the Dunhill Medical Trust and the Centre of Excellence for Personalized Healthcare funded by the Wellcome Trust and EPSRC.
The study will last for 5 years and over that time approximately 250 patients will be recruited. We will aim to scan the patients arriving within 6 hours of their symptoms an hour after arrival (once any treatment has been started) and then at 2-3 hours, 1 day, 5 days and 28 days. Patients arriving later than 6 hours after symptom onset will start the study at the 1 day scan. Some patients will be offered extra scans between day 1 and day 5 (no more than 1 per day). Blood samples may be taken at each scan time point within the first 7 days.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
13/SC/0362
Date of REC Opinion
5 Aug 2013
REC opinion
Favourable Opinion