AMBER: Assessing HPV-specific memory B-cell responses post vaccination

• Research type

  Research Study

• Full title

  AMBER: A pilot study to assess HPV-specific memory B-cell responses in healthy vaccinated women.

• IRAS ID

  233776

• Contact name

  Charles Lacey

• Contact email

  charles.lacey@hyms.ac.uk

• Sponsor organisation

  University of York

• Clinicaltrials.gov Identifier

  NCT02834637

• Duration of Study in the UK

  0 years, 6 months, 2 days

• Research summary

  Our study aims to collect some additional blood from young women aged 16-25 - who have been vaccinated against HPV - who are already attending a sexual health clinic for a blood test. This blood will be processed and used to develop our memory B-cell assay looking at the response to stimulation by HPV VLPs. We wish to determine if memory B-cells responding to HPV are still present several years after vaccination. The assay will later be used in a large randomised trial comparing two HPV vaccines (the DoRIS trial).

• REC name

  Yorkshire & The Humber - South Yorkshire Research Ethics Committee

• REC reference

  17/YH/0333

• Date of REC Opinion

  5 Oct 2017

• REC opinion

  Favourable Opinion