Alternative splicing of VEGF-A in Peripheral Arterial Disease (PAD)
Research type
Research Study
Full title
Alternative splicing of VEGF-A in Peripheral Arterial Disease (PAD)
IRAS ID
265512
Contact name
Bruce Braithwaite
Contact email
Sponsor organisation
NHS trust
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Many people with cardiovascular diseases have arteries that progressively block due to accumulation of fats. About half of these arteries can regrow new vessels to restore blood flow. However, in patients with cardiovascular disease and diabetes almost 85% of patients cannot form new blood vessels and their legs will eventually will lose function. They experience severe leg pain when walking and many will lose limbs or die of heart failure. The lack of healthy blood vessel growth occurs in part because white blood cells produce the wrong sort of protein, called VEGF-A165b, which stops blood vessels from regrowing. In this project we will collect blood from patients will peripheral arterial disease (PAD) with and without diabetes. The blood will be analysed to compare the expression of RNA and protein levels of VEGF-A165b that has been shown to be responsible for the inhibition of new blood vessels formation in several other diseases including cancer. This analysis will help us understand the factors that are present in patients withPAD and are responsible for the prevention of blood vessel formation.
REC name
North East - York Research Ethics Committee
REC reference
20/NE/0068
Date of REC Opinion
25 Feb 2020
REC opinion
Favourable Opinion