AKID: Acute Kidney Injury and Late Diabetes in Pregnancy
Research type
Research Study
Full title
AKID: Acute Kidney Injury and Late Diabetes in Preganancy – a prospective cohort study.
IRAS ID
246444
Contact name
Christy Burden
Contact email
Sponsor organisation
North Bristol Trust
Duration of Study in the UK
0 years, 10 months, 1 days
Research summary
1. Acute kidney injury (AKI) is a sudden decrease in the kidneys’ ability to filter blood, remove toxins and produce urine. AKI, even a mild form increases risk of future illness, including long-term Chronic Kidney Disease, heart attack and stroke. \n\nAt birth, women may have bleeding, dehydration, infections, use painkillers and undergo surgery (caesarean section), all of which are known to increase risk of AKI. We suspect some women have unidentified AKI after giving birth. However, detecting AKI is difficult because kidney function isn’t measured in all women after giving birth. Also, the blood test result used to measure kidney function changes in pregnant women anyway (kidney function measures increases during pregnancy and reduces after birth). This makes it difficult to decide if the blood test is changing because of AKI or because of normal, expected changes.\n\n2. Diabetes (sugar in the blood) can develop in pregnancy. If untreated, high blood sugar levels in pregnancy can cause many complications: large babies, problems during labour, higher risk of having caesarean section, and most importantly an increased risk of stillbirth. After the baby is born, it can have low blood sugars, and long-term health problems.\n\nAt present diabetes in pregnancy is diagnosed by ‘glucose tolerance test’ done at 24-28 weeks of pregnancy. Even if this tests does not show diabetes some women may go on to develop diabetes later in pregnancy. Currently, the best test to use for diabetes after 32 weeks of pregnancy is unknown. \n\nIn this study, we will measure kidney function in women during and after pregnancy, and look at normal levels of glucose in pregnant women after 32 weeks of pregnancy. With this information, we can define normal kidney function levels in pregnant women; identify episodes of AKI after giving birth; and find a way to diagnose late pregnancy diabetes. \n
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
19/YH/0173
Date of REC Opinion
9 Jul 2019
REC opinion
Favourable Opinion