AKI Dashboard
Research type
Research Study
Full title
Using real-time medical record data to identify rates of nephrotoxin co-prescribing and associated Acute Kidney Injury in hospitalised children.
IRAS ID
361936
Contact name
Louise Bracken
Contact email
Sponsor organisation
Alder Hey Children's NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 11 days
Research summary
Acute kidney injury (AKI) occurs when the kidneys suddenly stop working properly. It affects around 1 in 20 children in hospital. Although many recover, AKI can lead to complications during a hospital stay and may increase the risk of long-term kidney disease.
Some medicines can increase the risk of developing AKI. They are called 'nephrotoxins'. These medicines are often necessary, but the risk of them causing AKI increases when several are given together or when they are used for a long time. Research suggests that up to 1 in 4 children receiving three or more nephrotoxic medicines develop AKI. Earlier identification of children taking nephrotoxins could help prevent harm.
This study aims to develop a digital tool (AKI Dashboard) to help healthcare professionals identify children at risk of AKI from their medicines in real time. The tool will be developed using data which is routinely collected in electronic patient records. It will be designed with input from doctors, nurses, and pharmacists to ensure it is practical and easy to use. Feedback from staff will be gathered through interviews and focus groups.
We will use the dashboard to measure how often children are exposed to nephrotoxic medicines and how frequently AKI occurs. We will also explore whether certain groups of patients, including those from more disadvantaged backgrounds, are at higher risk.
A study advisory group, including families with experience of AKI and healthcare professionals, will guide the project. Patient and public involvement has already informed the study design.
Findings will be shared through publications and with families and staff. If successful, this approach could support earlier detection of AKI and improve the safety of medicines for children in hospital.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
26/NW/0125
Date of REC Opinion
13 May 2026
REC opinion
Favourable Opinion