AKI BioMAS: Acute Kidney Injury: Biomarkers in Major Abdominal Surgery
Research type
Research Study
Full title
Urine IGFBP-7/TIMP-2 for the prediction of Acute Kidney Injury following Major Abdominal Surgery
IRAS ID
243390
Contact name
Rishabh Singh
Contact email
Sponsor organisation
Research and Development, Royal Surrey County Hospital
Duration of Study in the UK
1 years, 6 months, 0 days
Research summary
The Kidneys filter waste products in the body. Major abdominal surgery carries a risk of developing Kidney Injury. This can have serious effects. Conventional methods of assessing kidney function – blood tests - often only detect it once it has been present for 48 hours. The longer the injury goes undetected, the lower the chance of recovery. A new urine test has been manufactured - the IGFBP-7/TIMP-2 test. Recent research in heart surgery patients has shown that it can detect injury to the Kidneys within 4 hours of the operation.
Our research hopes to show the same pattern in abdominal surgery. It is hoped that if a way is found of detecting injury to the kidneys earlier than conventional methods, protective strategies can be started sooner, potentially preserving kidney function.
In our study, urine samples will be obtained from patients 4 hours after they have undergone an operation. The IGFBP-7/TIMP-2 test will then be used. The results of this new test will be compared with the routine blood tests and observations that any patient would be required to have as part of their post-operative care.
The new test will be performed on samples from approximately 500 patients. We will then analyse all results to ascertain whether the new test could have identified a patient at high risk of developing Kidney Injury within a few hours of their operation.REC name
London - Queen Square Research Ethics Committee
REC reference
18/LO/0601
Date of REC Opinion
20 Apr 2018
REC opinion
Further Information Favourable Opinion