AIMS MS SMART
Research type
Research Study
Full title
Advanced inertial sensors to quantify disability progression in patients with secondary progressive Multiple Sclerosis taking part in the MS SMART clinical trial.
IRAS ID
183915
Contact name
David Paling
Contact email
Sponsor organisation
University of Sheffield
Duration of Study in the UK
0 years, 7 months, 1 days
Research summary
The aim of this study is to understand whether advanced gait analysis using inertial sensors is able to detect and quantify neurological disability in patients with multiple sclerosis and test its progression over time. The assessment of disability in patients with multiple sclerosis is complex. Inadequacies in current disability rating scales including poor reproducibility and lack of responsiveness are well recognised by the multiple sclerosis research community (Cohen et. al. 2012) and may have hampered previous attempts to test disease modifying treatments for progressive multiple sclerosis (Zaijcek et. al. 2013). Accurately measuring ambulatory dysfunction in patients with multiple sclerosis may be a more sensitive way of detecting changes in disability progression induced by disease modifying medication within the relatively short time frame of a clinical trial. Data from this study may help inform further clinical trial designs, and may provide more accurate methods of assessing disability progression in patients with multiple sclerosis in a clinical setting. We can confirm that any identifiable video footage would be used for research purposes only, and not for training purposes or in any publications without appropriate anonymisation.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
15/YH/0300
Date of REC Opinion
3 Sep 2015
REC opinion
Further Information Favourable Opinion