AFiRM Study v1.0
Research type
Research Study
Full title
Application of Functional Renal MRI to improve assessment of chronic kidney disease (AFiRM)
IRAS ID
271043
Contact name
Nicholas Selby
Contact email
Sponsor organisation
University Hospitals of Derby & Burton NHS Foundation Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
6 years, 5 months, 28 days
Research summary
We are conducting research to see if a special type of kidney MRI scan will provide new information about chronic kidney disease (CKD), which in future could be used to better guide treatments. The most commonly used method of visualising the kidneys in someone with kidney disease is a basic ultrasound scan. New types of MRI scans have been developed that produce much more detailed images of the kidneys as well as making other measurements of how well the kidney is working. These new MRI scans are not yet used for patient care, so we want to perform a research study to establish whether MRI scans will help patients with chronic kidney disease (CKD).
The study will recruit patients with CKD across 9 different centres in the UK, collect information from the medical records, take blood and urine samples and ask them to complete two short questionnaires. Participants will attend for four study visits, annually, in line with their routine appointments. At the baseline and year 2 visit, participants will have an MRI scan (which may be at the hospital or the local, affiliated university, according to infrastructure already in place and agreed) as well as their clinic visit.
There are two additional, optional components to the study; we will ask participants to consent to provide an additional blood and urine sample to be stored in a biobank for future research and for those who have had a kidney biopsy as part of their routine care, we will ask their consent to use any surplus tissue for analysis as part of a sub-study.
REC name
HSC REC A
REC reference
20/NI/0056
Date of REC Opinion
21 Apr 2020
REC opinion
Further Information Favourable Opinion