Advanced Ultrasound in Pleural Infection (AUDIO)
Research type
Research Study
Full title
Advanced ultrasound in pleural infection (AUDIO)
IRAS ID
168379
Contact name
Najib Rahman
Contact email
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
Pleural infection is a potentially serious infection of the fluid normally found around the lung and current evidence suggests that its incidence is increasing in both adult and paediatric populations.
Identification of bacterial pathogens causing pleural infection is of paramount importance in the clinical care of patients as currently, only 40% of patients have a laboratory confirmed microbiological diagnosis for their pleural infection. An unclear diagnosis can be due to various reasons such as a small sample volume therefore the aim of the AUDIO study is ascertain the capacity of pleural biopsies in improving the microbiological yield of pleural infection.
Currently, there are no well-validated methods for identifying patients presenting with pleural infection on the basis of initial ultrasound imaging. The AUDIO study will define the role of baseline thoracic ultrasound in predicting the radiographic, clinical and surgical outcomes of patients with pleural infection.The AUDIO study aims to recruit 50 patients from two centres with specific pleural expertise and these patients will be followed up over a 12 month period. We hope that through the information gathered from ultrasound imaging and pleural biopsies, it will aid physicians’ clinical and therapeutic decision making when treating patients with pleural infection.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
15/SC/0171
Date of REC Opinion
1 Apr 2015
REC opinion
Favourable Opinion