Advanced MRI in paediatric brain tumours.
Research type
Research Study
Full title
A feasibility study of advanced MRI imaging in paediatric brain tumours.
IRAS ID
338827
Contact name
Madeleine Adams
Contact email
Sponsor organisation
Cardiff and Vale University Health Board
Duration of Study in the UK
2 years, 0 months, 16 days
Research summary
The proposed study will assess the feasibility of using advanced MRI imaging for children aged 8-16 with newly diagnosed brain tumours, suspected low-grade gliomas (LGGs), at Cardiff University Brain Research Imaging Centre (CUBRIC). The comparison will be standard MRI, with feasibility measured by thematic analysis of satisfaction surveys from families, analysis of the patient population and addressing safety and practicality before embarking on a larger study.
It is not currently understood why certain LGGs behave more aggressively with higher rates of recurrence than others despite sharing the same histological (microscopic) and molecular genetic characteristics. For example, two patients with a low grade glioma may have tumours that appear the same under the microscope and share the same results on tests related to their DNA, but one may recur and spread throughout the brain and the other completely resolve.If this study was found to be successful, a larger study would be carried out to assess if advanced MRI, including detailed imaging of tumour structure, combined with genetic testing of the tumour and tumour bed after surgery may predict how likely the tumour is to grow back. It is hoped that the impact of understanding this would allow treatment to be taliored to individual needs.
REC name
East of Scotland Research Ethics Service REC 2
REC reference
25/ES/0002
Date of REC Opinion
18 Feb 2025
REC opinion
Further Information Favourable Opinion