Adjunctive inflammation-resolution therapy in MINST
Research type
Research Study
Full title
Adjunctive inflammation-resolution therapy in minimally-invasive treatment of deep periodontal intrabony defect: a pilot randomised controlled trial
IRAS ID
343438
Contact name
Luigi Nibali
Contact email
Sponsor organisation
Kings College London
Duration of Study in the UK
2 years, 2 months, 31 days
Research summary
The aim of this study is to assess whether and how a mouthwash containing an ingredient that reduces inflammation in combination with a recently developed treatment is more effective at improving advanced gum disease. Advanced gum disease, also called periodontitis, is an inflammation of the gums which results in decrease in bone levels supporting teeth and can result in tooth loss. Minimally invasive non-surgical treatment (MINST) is a type of periodontal deep cleaning which involves removal of plaque beneath the gum margin and reduces inflammation. In this trial we will assess the additional benefits of combining MINST treatment with the use of a mouthwash known to have a beneficial effect on tissue healing by helping the body to switch of inflammation in periodontitis. There will be two groups of patients including a control group, where patients will be treated by MINST and provided with a placebo mouthwash. The duration of the study will be over six months and will consist of a total of seven appointments. The aim of this study is to assess whether we can achieve better outcomes using this mouthwash and the healing of periodontitis will be assessed clinically. In addition, other clinical measurements such as saliva samples, blood samples and plaque samples will be collected throughout the study which allows us to examine the healing process of periodontitis in more detail and will help us understand how exactly the combination of MINST and the therapeutic mouthwash increase healing. Photographs will also be taken throughout the study to document the progress of the treatment.
REC name
West of Scotland REC 5
REC reference
25/WS/0123
Date of REC Opinion
11 Sep 2025
REC opinion
Further Information Favourable Opinion