Adherence to oral anticoagulants and statins - version 1
Research type
Research Study
Full title
The adherence to oral anticoagulants and statins project
IRAS ID
301790
Contact name
Rani Khatib
Contact email
Sponsor organisation
The Leeds Teaching Hospitals Trust
Clinicaltrials.gov Identifier
TBC (at review stage), Clinicaltrials.gov registration number
Duration of Study in the UK
0 years, 4 months, 0 days
Research summary
Adherence is the extent of a patient's commitment to a treatment plan as agreed between the patient and the prescribing clinician.
The project aims to understand adherence to direct oral anticoagulants (DOACs) and statins in Leeds. This includes understanding the levels of adherence, barriers to adherence and educational interventions to improve awareness and tackling of non-adherence by healthcare professionals.
During the first component, the investigation of rates of non-adherence was classed as service evaluation. The second component, which this IRAS application refers to, will look into patient perspectives and barriers to adherence. Currently, such information is not routinely collected and only requested as part of shorter or longer consultations depending on a pre-defined agenda and with little attention to adherence.Two specific questionnaires have been designed and integrated within the primary care systems. Following invitation for target patients on DOACs and/or statins to respond anonymously, responses will be stored in their medical records. Data will then be extracted from SystmOne using unique system identifiers, that will be pseudonymised at the time of extraction. All patient pseudonymised information will be extracted by the LTHT Researcher-Pharmacist following access provided by each participating GP Practice, based on searches built centrally by the Leeds Clinical Commissioning Group (CCG).
Apart from the dissemination of questionnaire findings, a training package for health professionals will be designed and delivered. The aim is to combine and disseminate all findings of the project, raise awareness on real-world non-adherence prevalence and the common barriers to adherence, demonstrate the usefulness of routine adherence estimation and suggest tools to address non-adherence in daily practice. The objectives will also consider the training needs of healthcare professionals locally, as per the healthcare professionals survey that has been circulated.REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
22/YH/0055
Date of REC Opinion
21 Mar 2022
REC opinion
Favourable Opinion