Adenosine Triphosphate Delivery Rates in Myocardial Hypertrophy
Research type
Research Study
Full title
Adenosine Triphosphate Delivery Rates in Myocardial Hypertrophy
IRAS ID
197866
Contact name
Oliver Rider
Contact email
Sponsor organisation
University of Oxford, Division of Cardiovascular Medicine
Duration of Study in the UK
2 years, 9 months, 16 days
Research summary
While thickening of the heart muscle (left ventricular hypertrophy) occurs naturally in response to exercise training (physiological thickening or “athletes heart”) it commonly occurs in response to heart disease (pathological), either pumping against a higher pressure (e.g. aortic valve narrowing) or pumping a larger volume of blood (e.g. mitral valve leak). Separating these two things is often difficult and the current methods used are not perfect. If left untreated, pathological thickening can lead to heart failure and therefore diagnosing pathological thickening can lead to earlier treatment. This research is aimed at finding out if a reduction in the amount of energy produced and delivered to the heart muscle in valve disease is one of the main reasons why the heart muscle thickens, and whether eventually, if energy levels fall low enough, the heart muscle starts to fail and the pumping function reduces.
We will answer this question by inviting 100 participants with several kinds of left ventricular hypertrophy and 20 participants with normal hearts to undergo assessment of heart energy delivery rates, left ventricle chamber dimensions, function, blood flow and scarring, heart valve disease severity, and exercise capacity using a combination of magnetic resonance imaging with gadolinium contrast and (in those participants without severe valve disease) simulated stress by injection of dobutamine, state-of-the-art magnetic resonance spectroscopy, ultrasound (in those participants with normal or athletic hearts), cardiopulmonary bicycle exercise testing and 6-minute walk testing at the University of Oxford Centre for Clinical Magnetic Resonance Research. Participants due to undergo clinically-indicated aortic valve replacement at the John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, will also have the option to donate a sample of heart muscle for analysis for energy delivery rates ex vivo and will be re-assessed after surgery.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
16/SC/0323
Date of REC Opinion
28 Jul 2016
REC opinion
Further Information Favourable Opinion