ADAPT-PD
Research type
Research Study
Full title
Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) Trial
IRAS ID
284253
Contact name
Sandra Jacobs
Contact email
Sponsor organisation
Medtronic
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 8 months, 1 days
Research summary
Deep Brain Stimulation (DBS) Therapy may be used to treat some of the motor complications of Parkinsons Disease that are not adequately controlled with medication. Deep Brain Stimulation Therapy is currently delivered in a continuous fashion (cDBS) where stimulation settings are constant and do not adjust to fluctuations in symptoms typically experienced by Parkinson’s disease patients during medication On and Off states.
The Medtronic Percept PC neurostimulator aDBS is a mode that adapts DBS therapy automatically based on certain brain signals within a range defined by the study doctor. The potential benefits of aDBS being more responsive to an individual patient’s clinical state include a reduction in PD symptoms and side effects and also increasing device battery longevity.
There are two types of aDBS (modes) being tested in this study; Single Threshold and Dual Threshold.
The purpose of this study is to evaluate the safety and effectiveness of adaptive Deep Brain Stimulation (aDBS) for Parkinson’s Disease.REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
20/WM/0243
Date of REC Opinion
28 Oct 2020
REC opinion
Further Information Favourable Opinion