Acute physiological response to exercise in end stage renal disease
Research type
Research Study
Full title
An investigation into the acute physiological response to maximal and steady state exercise in End Stage Renal Disease.
IRAS ID
216816
Contact name
Scott McGuire
Contact email
Sponsor organisation
Coventry University
Clinicaltrials.gov Identifier
P48089, Coventry University Ethical Approval
Duration of Study in the UK
2 years, 6 months, 1 days
Research summary
Chronic kidney disease (CKD) affects between 5-10% of the world’s population, equating to ~740 million people worldwide (Kidney international 2009). End stage renal disease (ESRD) is the result of a progressive loss of kidney function where the patient requires dialysis to replace the typical functions of the kidney (Kidney international 2009). The quality of life of these individuals can be poor as a result of various complications associated with CKD (e.g. heart disease, diabetes, muscle wastage, decreased fitness)(Gould et al. 2014). In an attempt to combat reduced physical fitness, many studies have applied long term exercise programmes. However, the body's response to exercise in people with CKD is not well understood and a set of guidelines that informs safe and effective exercise prescription is lacking.
The use of exercise as treatment in ESRD has grown in popularity, and evidence provided by research indicates improvements to the heart, lungs and muscles (Segura-Orti 2010). Despite these positive findings, the specific mechanisms through which exercise benefits these patients have not yet been fully established. In addition, the extent to which ‘normal’ physiology is acutely altered by dialysis treatment, and the effect that aerobic exercise may have on this, is unknown.
In patients with ESRD, patients will be exercised at the university hospital Coventry and Warwickshire dialysis unit with the aim to understand the acute physiological response to exercise under different conditions. The total study time for 1 individual will be a minimum of 1 month and a maximum of 2 months (accounting for illness, unable to attend appointments), each individual will undergo cycling exercise, blood withdrawal via the arm and a chest scan (echocardiogram). In doing so, the study aims to inform the development of guidelines for safe and effective dialysis exercise training.
REC name
London - City & East Research Ethics Committee
REC reference
17/LO/0356
Date of REC Opinion
15 Feb 2017
REC opinion
Favourable Opinion