Acute Kidney Injury aNd paracetamol overDose
Research type
Research Study
Full title
Acute Kidney Injury aNd paracetamol overDose (KIND)
IRAS ID
333818
Contact name
Stephen McWilliam
Contact email
Sponsor organisation
Alder Hey Children's Hospital
Duration of Study in the UK
0 years, 6 months, 30 days
Research summary
This research project focuses on understanding a lesser-known complication of paracetamol overdose – acute kidney injury (AKI). While liver injury is commonly associated with paracetamol overdose, this study aims to shed light on the occurrence of AKI, a rapid decline in kidney function.
We hypothesise that AKI might be occurring more frequently than currently recognised, especially in cases where patients are sent home within a day after paracetamol overdose. We will conduct follow-up visits with patients 2-3 days after the overdose to assess the incidence of AKI. As the traditional test for AKI, called creatinine, can be delayed in detecting the condition, we will also evaluate the feasibility of using a newer kidney injury marker called Kidney Injury Molecule-1 (KIM-1) for early detection.
The study will involve young people who have intentionally overdosed on paracetamol and attend the Emergency Department at Alder Hey Children’s Hospital. Here they will be managed according to existing protocols. They will receive information about the study during their visit and will be offered a follow-up appointment. At this appointment consent will be obtained for additional tests to check for AKI and to store blood and urine samples for later analysis of kidney injury biomarkers.
Patients with positive AKI test results will receive appropriate treatment, while those with negative results will be discharged without further follow-up. We aim to recruit around 25 patients within a year, as this is feasible given the number of paracetamol overdose cases usually seen each month.
The potential impact of this study is significant. By identifying cases of AKI early, especially when patients first arrive at the hospital, interventions can be initiated promptly, potentially reducing the occurrence of AKI. This research could lead to improved protocols for managing paracetamol overdose and better outcomes for patients in the future.
REC name
London - Central Research Ethics Committee
REC reference
25/PR/0023
Date of REC Opinion
1 Apr 2025
REC opinion
Further Information Favourable Opinion