Acute deterioration, sepsis and AKI research database
Research type
Research Database
IRAS ID
298672
Contact name
Guy Glover
Contact email
Research summary
GSTT acute deterioration, sepsis and AKI research database
REC name
London - South East Research Ethics Committee
REC reference
21/LO/0584
Date of REC Opinion
15 Oct 2021
REC opinion
Further Information Favourable Opinion
Data collection arrangements
The database will be formed by aggregating routinely collected clinical and administrative data from the existing health record at Guy's and St Thomas' NHS Foundation Trust (GSTT), using a data warehouse methodology, stored on GSTT servers and subject to all principles of information governance. The focus is on the field of acute deterioration (meaning detection, escalation and response to physiological derangement), sepsis and acute kidney injury (AKI). Specific fields will include, but may not be limited to:
- Patient demographic details including age, gender, race
- Patient clinical characteristics including co-morbidity and frailty based on assigned diagnosis in the clinical record or from discharge coding
- Visit characteristics such as admission type and provider specialty
- Longitudinal physiological observation data including early warning scores
- Pathology data including routine blood orders / results (with associated AKI alerts), microbiology culture orders / results
- Radiology orders and results
- Pharmacy orders including antimicrobials, oxygen and fluid orders, other medication orders relevant to sepsis / AKI
- Selective clinical medical / nursing notes, specifically as they relate to escalation calls, rapid response team review records, sepsis screening and sepsis bundle administrationResearch programme
Patient acute deterioration, sepsis and acute kidney injury are NHS patient safety priorities, on the basis that they are common events in hospital and are associated with worse patient outcomes and high use of resources. As such they are important subject-areas for patients, clinicians and healthcare systems. To this end Guy’s and St Thomas’ NHS Foundation Trust (GSTT) is developing a series of subject-area quality improvement projects supported by a data warehouse and with associated data visualisation tools. It is anticipated that this data will generate opportunities for generalizable research of a retrospective nature. Examples may include the validation of existing systems, or derivation of novel systems for the detection of acute deterioration, sepsis or AKI; exploration of relationships between diagnosis or specific elements of care and patient outcomes and temporal trends over time.
Research database title
GSTT acute deterioration, sepsis and AKI research database
Establishment organisation
Guys and St Thomas' NHS Foundation Trust
Establishment organisation address
Westminster Bridge Road
London
SE1 7EH