Activity and fatigue during chemotherapy for Oesophagogastric cancer
Research type
Research Study
Full title
An investigation into activity and fatigue during neoadjuvant chemotherapy in patients with oesophagogastric adenocarcinoma.
IRAS ID
186987
Contact name
Rhona Sinclair
Contact email
Sponsor organisation
Newcatle upon Tyne Hospitals Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
This is a simple prospective exploratory study designed to observe the effects of chemotherapy upon activity levels in patients with oesophagogastric cancer (gullet and stomach cancer) who are receiving chemotherapy, prior to radical surgery. We will observe intensity of patient movement using accelerometers (watch like monitors) worn on the wrist and compare activity at certain timed points during treatment. Patients will also be asked to complete fatigue scores, international physical activity questionnaires and day time sleepiness scores at these time points.
We will monitor activity for 7 days during 5 time periods: before chemotherapy, during the first week of chemotherapy, the middle week of intended chemotherapy, the final week of intended chemotherapy and week 4 following cessation of chemotherapy.
We intend to observe activity levels in patients with these malignancies during neoadjuvant chemotherapy and to compare this to activity prior to treatment and to self-reported data and clinician estimated performance status. We also wish to assess the burden of the monitoring on patients with a view to the practicality of further studies using this equipment.
We hypothesise that this study may demonstrate a reduction in activity levels in this patient group when compared to their activity levels prior to commencing treatment. We hope that ultimately this may inform further studies aimed at maintaining activity and fitness levels prior to major surgery.REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
15/NW/0891
Date of REC Opinion
10 Nov 2015
REC opinion
Favourable Opinion