Active breaks in people with type 1 diabetes (EXTOD-Active)

• Research type

  Research Study

• Full title

  The effect of interrupting sitting with regular active breaks on glycaemia and daily insulin dose in sedentary people with type 1 diabetes

• IRAS ID

  317327

• Contact name

  Matthew Cocks

• Contact email

  m.s.cocks@ljmu.ac.uk

• Sponsor organisation

  Liverpool John Moores University

• Clinicaltrials.gov Identifier

  NCT05706298

• Duration of Study in the UK

  0 years, 8 months, 31 days

• Research summary

  Sedentary behaviour (SB; sitting or lying down for prolonged periods), was recently identified as a public health problem independent to that of physical inactivity. Conversely, data suggest that frequent breaks in sedentary time are associated are associated with health benefits, including greater time in target glycaemic range in people with type 2 diabetes. Hence, frequent active breaks from sedentary behaviour may offer a pragmatic public health intervention for improved glycaemic control. However, in people with type 1 diabetes (T1D) we understand much less about how sedentary behaviour and active breaks influences glycaemic control. Therefore, interventions that investigate the efficacy of breaking sedentary time with short active breaks in sedentary people with T1D are needed.

  Therefore, the aims of this study are to investigate the influence of interrupting prolonged sitting with scheduled active breaks (3 mins of walking every 30 min) in people with T1D with high habitual sedentary behaviour on:
  1) Time in target glycaemic range
  2) Other markers of glycaemic control, including HbA1c and glucose variation
  3) Daily insulin dose
  4) Wellbeing

  118 people with T1D who are habitually sedentary will be randomised to either 4 weeks of habitual activity (control) or active breaks. Participants in the active breaks condition will be asked to interrupt sitting with 3 min bouts of walking every 30 min from 9am-5pm every day throughout the 4 week period. Activity, interstitial glucose, insulin dose and carbohydrate intake will be monitored throughout. Participants will complete a health assessment pre- and post-intervention.

• REC name

  West Midlands - Solihull Research Ethics Committee

• REC reference

  22/WM/0221

• Date of REC Opinion

  17 Nov 2022

• REC opinion

  Further Information Favourable Opinion