ACIC Vs MCIC

• Research type

  Research Study

• Full title

  A study to compare two articular cartilage repair techniques in the knee joint: Autologous Collagen Induced Chondrogenesis (ACIC) Vs. Mesenchymal Cell Induced Chondrogenesis (MCIC).

• IRAS ID

  120868

• Contact name

  Ananthram Shetty

• Sponsor organisation

  Department of Minimally Invasive Surgery, Canterbury Christ Church University

• Research summary

  Study Title: A study to compare two articular cartilage repair techniques in the knee joint: Autologous Collagen Induced Chondrogenesis (ACIC) Vs. Mesenchymal Cell Induced Chondrogenesis (MCIC).

  Trial Design: This is a prospective study. The participating patients will be divided into two groups, each group receiving either one of the treatment modalities. This study will not be randomised or blinded. Both procedures will be done at the Spire Alexandra Hospital by Professor A. A Shetty, who is one half of the team that devised both techniques.

  Trial Participants: All participants will be from patients attending Professor Shetty’s clinic at the Spire Alexandra Hospital.

  Planned Sample Size: 50 patients in each arm.

  Follow-up duration: The participating patients will be followed up at 2 weeks, 6 weeks, 3 months, 6 months, 1 year and 2 years following the surgery by visits to the clinic and assessed clinically. The surgical outcomes will be measured by by IKDC, KOOS and Lysholm scores; cartilage growth will be measured by the MOCART score.

  Planned Trial Period: Two to three years

  Primary Objective: To establish superiority, if any, of either procedure over the other.

  Primary Endpoint: At the end of the 2 year follow up for all participating patients.

• REC name

  London - Camden & Kings Cross Research Ethics Committee

• REC reference

  13/LO/1780

• Date of REC Opinion

  22 Apr 2014

• REC opinion

  Further Information Favourable Opinion