ACED Cohort

• Research type

  Research Tissue Bank

• IRAS ID

  369548

• Research summary

  Alliance for Cancer Early Detection (ACED) Cohort

• REC name

  East of England - Cambridge South Research Ethics Committee

• REC reference

  26/EE/0134

• Date of REC Opinion

  5 Jun 2026

• REC opinion

  Favourable Opinion

• Data collection arrangements

  The aim of the ACED cohort is to collect clinical, demographic, physiological and epidemiological information, and store linked biological samples (e.g. DNA, blood, blood derivatives and urine) from adults to establish a cohort to
  better understand risk factors for cancer and to detect cancers at earlier stages.
  Participants will be consented for their samples donated to ACED Clinic Cambridge and data generated from the samples will to be used for genetic, biomedical studies and clinical trials.
  Upon enrolment, each participant will give consent, complete a risk-profiling, quality of life, clinical and lifestyle questionnaire to provide comprehensive cancer risk prediction on the basis of genetic and non-genetic factors.
  Participants will have a standard set of samples collected (e.g. urine, blood and derivatives - refer to Table 1 in protocol) for biomarker profiling, which will be designed to maximise utility across different applications.
  The participant may donate up to 50mls or less of blood through venepuncture by qualified staff on an annual basis. There may be some instances where the visit could be more frequent depending on the participant risk profile. Samples will be processed to obtain cells, nucleic acid (DNA/RNA), plasma, serum and whole blood.
  All these materials will be accessible for future studies where they may be analysed, genotyped, amplified, logged and stored for future use in research over an indefinite period. These samples will be primarily held at the CCRC (Cambridge Clinical Research Centre) and at the Early Cancer Institute facilites as part of the ACED Cohort but alternative archiving facilities may be used from time-to-time.
  

• Storage license

  12315

• RTBTitle

  Alliance for Cancer Early Detection (ACED) Cohort

• Establishment organisation

  Department of Oncology, University of Cambridge

• Establishment organisation address

  Early Cancer Institute

  Box 197, Cambridge Biomedical Campus

  Cambridge

  CB2 0XZ