Acceptability of risk-based breast cancer screening v1.0
Research type
Research Study
Full title
Acceptability of personalised risk-based breast cancer screening and prevention approaches among women in Europe
IRAS ID
202669
Contact name
Gareth Evans
Contact email
Sponsor organisation
University Hospital of South Manchester
Duration of Study in the UK
1 years, 7 months, 31 days
Research summary
Rationale: To counter the increasing burden of breast cancer for European women, better strategies for primary and secondary prevention are urgently needed. Personalised risk-based approaches may help target screening and primary prevention for breast cancer to women who will benefit most while sparing costs and complications among women who would experience less benefit. However, little is known about the acceptability of personalised approaches, especially for women at low risk, and the challenges of implementation, providing the rationale for the current proposal.
Objective: To provide insight in the acceptability of personalised risk-based breast cancer screening and primary prevention approaches for European women.
Study design: A mixed method study combining qualitative research methods (concept mapping and focus groups) with quantitative research (online questionnaire survey).Study population: Healthy women aged 47-73 years
Main study parameters/endpoints: The main study parameter is acceptance of personalised risk-based breast cancer screening. The endpoint will be reached using the following three methods:
1. Concept mapping with healthcare professionals. Concept mapping is a qualitative interview approach to assessing which aspects professionals (n=15-20) feel might affect women’s perceptions on personalised risk-based breast cancer screening and primary prevention (time investment 60 minutes).
2. Focus group interviews will be organised to identify unforeseen topics that may not arise from the literature search (n = 20-75). Focus group discussions will be organised until thematic saturation has been achieved. The discussions will be recorded and transcribed verbatim and anonymously in the original language (English). The information from the transcripts will be analysed using a systematic six-step strategy by Braun and Clarke (2006). The results from the interviews will be used in the construction of a questionnaire survey.
3. An online questionnaire survey will be conducted, made-up out of items identified through the systematic literature search and the focus group interviews, among a representative sample of women (n = 250-500) using different hypothetical risk-based screening and primary prevention scenarios. The aim of the questionnaire survey is to gain quantitative insight into the predictors of acceptance of personalised risk-based breast cancer screening. Multivariate logistic regression will be performed to identify predictors of compliance with personalised risk-based breast cancer screening and primary prevention approaches.REC name
London - West London & GTAC Research Ethics Committee
REC reference
16/LO/0810
Date of REC Opinion
22 Apr 2016
REC opinion
Unfavourable Opinion