Accelerating Endogenous Tissue Repair and Regeneration
Research type
Research Study
Full title
Accelerating Endogenous Tissue Repair and Regeneration
IRAS ID
213014
Contact name
Jagdeep Nanchahal
Contact email
Sponsor organisation
University of Oxford
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Humans inevitably encounter injury throughout our lifetimes, and our bodies have the remarkable capacity to repair themselves to most injuries. However various factors such as age, chronic diseases, and massive injury can affect our ability to repair and regenerate tissue. With a growing ageing population, higher rates of chronic diseases, and increasing incidences of injury, understanding how to accelerate and improve our ability to repair and regenerate tissue is of critical importance, and would substantially benefit our community.
Through use of animal models, we have identified a molecular target that accelerates regeneration of various tissues. We are now seeking to assess if that same molecule is relevant to human tissue regeneration. Therefore we will be measuring the changing levels of this and other molecules in the blood from patients who have suffered injury, and compare to no-injury controls. We will not be taking any extra blood from patients, as we are able to use whatever is ‘leftover’ from blood samples that were already taken as part of the patient’s standard care. We will be collecting these ‘leftover’ samples from the clinical laboratory, after they have already been de-identified. We would emphasise that these blood samples would normally be discarded by the hospital laboratory.
REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
16/SW/0263
Date of REC Opinion
23 Aug 2016
REC opinion
Favourable Opinion