AC-LPI
Research type
Research Study
Full title
Effect of mydriasis on intraocular pressure in patients with chronic angle closure, patent laser peripheral iridotomies and normal baseline intraocular pressures.
IRAS ID
190142
Contact name
John Salmon
Contact email
Sponsor organisation
Oxford University Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
This is a study investigating how pupil dilation affects eye pressure in people who have had successful laser treatment for narrow drainage angles. The purpose of such laser treatment is to try to prevent a sight-threatening pressure rise in the eye. Evidence exists that shows that an older surgical procedure, conducted with the same aim, was effective in controlling the pressure in eyes with dilated pupils in most cases. The effect of our current commonly used dilating eye drops on eyes that have had more modern laser treatment, however, remains unclear.
We plan to recruit adult participants with longstanding narrow drainage angles, who have previously been treated with a YAG laser peripheral iridotomy. This is a small hole in the iris that is designed to prevent an eye pressure rise caused by fluid building up behind the iris. Eligible, consenting participants will have one study visit in which they will be asked about their medical history. They will then have measurements of the affected eyes done, including 3 eye pressure checks (baseline, 1 hour and 2 hours after instillation of our departmental standard dilating eye drops - tropicamide 1% and phenylephrine 2.5%) and detailed ultrasound scans of the eye.
All appointments will take place in the Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust. Once the participant has been discharged after their study visit, with adequately controlled eye pressures, then their involvement with the study will be complete.
If the final results of this study show that dilating pupils in this way has a significant impact on eye pressure then our plan would be put precautionary measures in place to ensure that the pressure is monitored and treated, if appropriate, in patients who have narrow angles, have had laser successful laser treatment and who need to have their pupils dilated.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
16/SC/0211
Date of REC Opinion
23 May 2016
REC opinion
Further Information Favourable Opinion