ABOUT - K study

  • Research type

    Research Study

  • Full title

    A prospective, multi-centre, observational study evaluating an antigen-specific antibody removal protocol for ABO-incompatible renal transplantation in the UK

  • IRAS ID

    4310

  • Contact name

    Simon Ball

  • Sponsor organisation

    University Hospital Birmingham Charitable Trust

  • Eudract number

    2008-005498-36

  • ISRCTN Number

    N/A

  • Research summary

    This study aims to assess the outcomes of ABO-incompatible kidney transplantation in the UK with current practice. The primary aim is to assess the prevalence of acute rejection in ABO incompatible (ABOi) kidney transplantation in the UK. A secondary aim is to evaluate the safety and efficacy of the treatment protocols used in various UK centres for ABO incompatible transplantation; the occurrence of adverse events (including opportunistic infections); to assess anti A/B blood group antibody (IgG & IgM) titres pre- and post-transplantation and to assess the presence of non-ABO blood group antibodies post-transplantation.

  • REC name

    West Midlands - South Birmingham Research Ethics Committee

  • REC reference

    08/H1207/293

  • Date of REC Opinion

    26 Nov 2008

  • REC opinion

    Favourable Opinion