Ablation by Mapping
Research type
Research Study
Full title
Catheter Ablation of Cardiac Arrhythmias by Electroanatomical Mapping: A Study of Safety, Efficacy, Substrate and Validation
IRAS ID
223798
Contact name
Tom Wong
Contact email
Sponsor organisation
Royal Brompton and Harefield NHS Foundation Trust
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Cardiac arrhythmias are quite common in the general population. Such kind of heart rhythm disorder could either interfere with the quality of life or even be life threatening when the heart rate is too fast to pump enough blood to supply the brain and the other organs. \n\nMedications are one method to treat the rapid and irregular heartbeats for most people. However, the success rate of medications for cardiac arrhythmias was limited. Additionally, they may cause side effects in some people. As increasing widespread development of technology, catheter ablation is considered as another essential way to cure the abnormal heart rhythm, in particularly, for the patents with medication refractory arrhythmias or complex heart rate disorder. \n\nCatheter ablation is a procedure that uses radiofrequency energy to modify a small area of heart tissue that is causing rapid and irregular heartbeats. A better understand of mechanisms and substrate of different arrhythmias based on the maps helps increase the success rate of ablation and optimize the use of mapping system in the future. \n\nWe aim to recruit from existing cardiology patient population of Royal Brompton and Harefield NHS Foundation Trust. Patients who are referred for catheter ablation of arrhythmias could be enrolled and the related mapping and ablation data would be collected. After their ablation, participants would be followed up for one year as a part of their standard routine clinical care for incidence of arrhythmia. This allows us to observe the safety, efficacy of the ablation procedure as well the mechanisms and substrate of arrhythmia based on the mapping during the procedure. \n\nInformation gained from this research can supplement strategies to refine risk assessment of catheter ablation in patients with different cardiac arrhythmia, and to help optimize the use and develop the mapping system in the future.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
17/LO/1866
Date of REC Opinion
16 Feb 2018
REC opinion
Further Information Favourable Opinion