Abdominal Aortic Biomechanics and Biochemistry
Research type
Research Study
Full title
Investigation of the Biomechanics and Biochemistry of the Abdominal Aorta
IRAS ID
280653
Contact name
Martin Hossack
Contact email
Sponsor organisation
University of Liverpool
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
The aims of this research project are to investigate the biomechanical and biochemical changes that occur in the diseased abdominal aorta. This will aid in the understanding of the cause of aortic diseases such as abdominal aortic aneurysm, aortic dissection and atherosclerosis. It will also help to understand why aortic aneurysms of a similar size have varying rates of expansion and rupture, and improve the management of patients with aneurysmal disease by contributing to the development of a personalised risk of rupture.
The study will involve the harvesting of aortic wall tissue and associated thrombus from consented adult (>18) patients undergoing open aortic surgery in Vascular Theatres at The Royal Liverpool University Hospital. This tissue is redundant and is not required to perform repair of the aorta. Harvested tissue will be stored in a tissue biobank, after processing, and collected when needed for analysis. Tissues will be analysed across 2 sites in the University of Liverpool (School of Engineering and Institute of Integrative Biology). Baseline demographic, clinical and radiological data will also be collected from hospital records. The results will be published in peer-reviewed journals, presented at scientific conferences and form a PhD thesis for a vascular surgical trainee.REC name
East of England - Essex Research Ethics Committee
REC reference
20/EE/0210
Date of REC Opinion
2 Oct 2020
REC opinion
Further Information Favourable Opinion