A study comparing Phrenic Nerve Infiltration vs No infiltration.
Research type
Research Study
Full title
Randomised prospective study comparing Phrenic Nerve Infiltration vs Non-Phrenic Nerve Infiltration on Open Thoracotomy.
IRAS ID
132359
Contact name
Rajesh Shah
Contact email
Sponsor organisation
Research and Development at University Hospital of South Manchester NHS Foundation Trust.
Research summary
Thoracotomy is one of the most common procedures performed worldwide for lung diseases. Despite recent advances in anaesthesia for controlling the postoperative pain, many patients still report severe shoulder, surgical site and central back pain.There is a currently a paucity of data within the literature regarding the use of bupivacaine for phrenic nerve infiltration following open thoracotomy in regards to outcome measures and the associated benefit in reducing post-operative pain. We therefore intend to perform a randomised controlled study to assess whether the peri-operative use of phrenic nerve infiltration affects the post-operative pain score (measured using the visual analog and Likert scales) and peak flow pressure during incentive spirometry.The study is a single centre, randomised blinded prospective study. We propose to recruit 100 patients who are listed for elective and urgent inpatient for open thoracotomy/lobectomy procedure. These patients will be allocated to 50 patients in each group with computerised block randomisation to receive phrenic nerve infiltration or no phrenic nerve infiltration during their surgical procedure. They will involved in this study until their discharge from the hospital.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
14/NW/0003
Date of REC Opinion
3 Mar 2014
REC opinion
Further Information Favourable Opinion