A prognostic model for abdominal wall reconstruction
Research type
Research Study
Full title
A prognostic model for abdominal wall reconstruction; what peri-operative parameters predict successful ventral hernia repair?
IRAS ID
223846
Contact name
Steve Halligan
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
CRD42016043071, Protocol registered with Prospero
Duration of Study in the UK
2 years, 6 months, 0 days
Research summary
Synthesis of a prognostic model for ventral hernia recurrence after surgical repair.
A retrospective study of 1183 ventral hernia repairs performed at UCLH since 2007; sponsored by UCL.
Own account work funded by LifeCell EMEA and the NIHR Biomedical Research Centre. An application to the NIHR for a grant for this project has been submitted.
Ventral hernias are becoming increasingly large and frequent. Patients often suffer from chronic abdominal and back pains, chronic diarrhoea and respiratory dysfunction due to abdominal wall failure. In addition, these patients are often obese and have multiple comorbidities. Surgical repair is consequently challenging and can be unsuccessful. After extensive literature review, there is currently no ventral hernia prognostic model that predicts hernia recurrence at one year post repair. A prognostic model would be highly useful in the clinical setting, as failed ventral hernia repairs are expensive to healthcare systems and have no benefit to patients. Predicting the probability of operative success, will allow us to make an informed decision on whether or not attempt surgical management.
Research plan:
1) Extensive systematic review to identify prognostic risk factors for ventral hernia recurrence.
2) Preparation of our local individual patient data (IPD) for model development and internal validation. We will include CT scan dimensions as these may be potential imaging predictors.
3) External validation of pre-existing ventral hernia grading scales or models using our IPD.
4) Development of two new models for ventral hernia recurrence using our IPD. Model 1 will be based on standardly collected data, model 2 will include the additional CT variables.We have started the process of systematic review. We aim to finish this project by August 2019. Individual patient data collection will occur at UCLH, data analysis and prognostic model synthesis will occur at both sites, UCLH and Birmingham University.
REC name
North West - Haydock Research Ethics Committee
REC reference
17/NW/0526
Date of REC Opinion
13 Sep 2017
REC opinion
Favourable Opinion