A pilot study to assess tolerability of low temperature haemodialysis

• Research type

  Research Study

• Full title

  A pilot study to assess tolerability of low temperature haemodialysis and continuous intradialytic electroencephalograpy (in a subset)

• IRAS ID

  197011

• Contact name

  Indranil Dasgupta

• Contact email

  Indranil.Dasgupta@heartofengland.nhs.uk

• Sponsor organisation

  Heart of England NHS Foundation Trust

• Duration of Study in the UK

  0 years, 1 months, 1 days

• Research summary

  This is a pilot study to assess whether patients with kidney failure are able to tolerate haemodialysis using a lower (35C) temperature dialysis solution than standard (36C). The rationale behind using cool dialysis solution is that it helps to maintain blood pressure during dialysis and this has recently been shown to reduce harmful effects of haemodialysis on the heart and the brain. Impairment of cognitive function is common in haemodialysis patients. Our own research suggests that there is significant decline in cognitive function over a single session of dialysis. Research suggests that cooler dialysis may slow decline of cognitive function. The aim of this pilot study is to asses whether patients are able to tolerate cool temperature and will be willing to take part in a longterm study looking at the effect of this on cognition.
  Ten haemodialysis patients will be dialysed using a temperature of 35C on 3 consecutive occasions over a week. They will be observed closely by monitoring of temperature, blood pressure, pulse rate, oxygen saturation, and ECG. Two patients will also have brain activity assessed (electroencephalography, EEG) during one of the dialysis sessions. Tolerability will be assessed by a brief questionnaire. They also be asked if they will be willing to take part in a study lasting 12 months involving low temperature dialysis. This and the feasibility of carrying out EEG will inform design of the larger study.

• REC name

  East Midlands - Derby Research Ethics Committee

• REC reference

  16/EM/0290

• Date of REC Opinion

  29 Aug 2016

• REC opinion

  Further Information Favourable Opinion