A novel physiological assessment of the microcirculation in PPCI
Research type
Research Study
Full title
A Novel Index for Physiological Assessment of Coronary MicroVascular Injury during Primary Percutaneous Coronary Intervention (ASSESS-MVI study)
IRAS ID
220501
Contact name
Gerald Clesham
Contact email
Sponsor organisation
Basildon & Thurrock University Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 6 months, 2 days
Research summary
Heart attack patients are usually found to have blocked coronary arteries and modern stenting techniques are used to open up the blood vessel and restore blood flow. Whilst stents are good at opening up the main blocked vessel it is recognised that flow in the tiny blood vessels of the heart muscle (microcirculation) comes back to normal in less than half of the patients, a phenomenon called microvascular injury.
At the moment microvascular injury can be detected with complex methods requiring special equipment and usually after the index procedure.
The aim of this study is to introduce and validate a new method for the assessment of microvascular injury in patients with acute heart attack, measured with a safe and easily performed way, using widely available equipment.
The study will take place immediately after the occluded vessel has been opened and a stent has been placed (routine treatment for heart attack). The research procedure will involve passing a wire and a balloon over the wire down the artery to record pressure, resistance and blood flow in the heart vessel. The equipment (wire and balloon) are standard tools that are routinely used during stent placement in heart vessels. We will use these measurements to create a new index of microvascular injury and assess its correlation with other measures of microvascular injury, which are already validated and in clinical use.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
17/EE/0334
Date of REC Opinion
11 Oct 2017
REC opinion
Further Information Favourable Opinion