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A Multicentre Biomarker Study in Neurodegeneration

  • Research type

    Research Study

  • Full title

    A Multicentre Biomarker Study in Neurodegeneration

  • IRAS ID

    204405

  • Contact name

    Heather House

  • Contact email

    ouhtma@ouh.nhs.uk

  • Sponsor organisation

    University of Oxford

  • Duration of Study in the UK

    5 years, 0 months, 0 days

  • Research summary

    The purpose of this study is to investigate possible causes of damage to motor nerves in motor system disorders, in particular, Motor Neuron Disease (MND), and to find biological markers (biomarkers) of disease activity. We aim to obtain blood, cerebrospinal fluid, urine, and small skin samples from people with MND, people with other neurological conditions including disorders that mimic some of the symptoms of MND, and people who are neurologically healthy. We will then analyse these samples to look for genes and other biomarkers that can tell the difference between people with MND versus people without any neurological disorder, as well as between people with MND versus people with other disorders. We will also look for genes and other biomarkers that can predict how different symptoms will develop and how quickly this will happen. Identification of biomarkers that allow us to measure disease activity in MND and other neurological conditions can help speed up diagnosis, better predict how someone's symptoms will progress, better plan clinical trials of new treatments, and help understand the underlying causes of MND, related conditions, and other neurological disorders. Eventually, all of this knowledge may contribute towards the development of new treatments.

  • REC name

    London - South East Research Ethics Committee

  • REC reference

    16/LO/2136

  • Date of REC Opinion

    24 Feb 2017

  • REC opinion

    Further Information Favourable Opinion