A High-Speed Clinical Diagnostics Instrument using LAP-MALDI MS
Research type
Research Study
Full title
A Cost-Effective High-Speed Clinical Diagnostics Instrument for Large Population Screening Based on Novel Liquid AP-MALDI MS Technology
IRAS ID
314790
Contact name
Rainer Cramer
Contact email
Sponsor organisation
University of Reading
Duration of Study in the UK
3 years, 11 months, 30 days
Research summary
The aim of the project is to develop a new method for rapid (clinical) diagnostics of disease using a mass spectrometric platform. Samples will be screened for markers of disease which can be accurately detected by mass spectrometry (MS).
Within this project we want to extend our knowledge from laboratory samples and veterinary disease detection to other biological matrices, including human biofluids. MS has the potential to bring advancements to the health services, particularly for mass testing campaigns, for example of infectious diseases.
For this, we will use biological fluids that are mainly non- or minimally invasively collected, such as oral or nasal fluid, urine, and blood, as well as sebum. Only small volumes (typically <1-10 mL) will be collected per sample.
The research project is funded by the Engineering and Physical Sciences Research Council (EPSCR) for a period of 3 years. Clinical samples will be collected from patients undergoing normal clinical care at the Royal Berkshire Hospital.
We aim to [A] develop new sample preparation protocols that are adequate for MS analysis and [B] build reliable models for disease classification using mass spectral features.REC name
South Central - Oxford A Research Ethics Committee
REC reference
22/SC/0380
Date of REC Opinion
2 Dec 2022
REC opinion
Further Information Favourable Opinion