A genomic analysis of asthma in twins
Research type
Research Study
Full title
Longitudinal Epigenomic Analysis in Identical Twins with Asthma
IRAS ID
164810
Contact name
Keith Brennan
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
TEDS E-Risk Study, REC/1997
Duration of Study in the UK
1 years, 1 months, 30 days
Research summary
The overall goal of this study is to examine the role of genomic variation in asthma. This will lead to a better understanding of the molecular mechanisms involved in a chronic illness which affects 5.4 million people in the UK. Despite considerable research effort we are still a long way from realising the underpinnings of asthma and it is hoped that this project will allow us to understand the condition and ultimately the development of novel therapeutic strategies for asthma. Participants will be selected from a current study, the TEDS Environmental Risk Longitudinal Twin Study (E-Risk) which is a longitudinal twin study that has previously collected information regarding their history of asthma. All participants will be identical twin pairs and selected based on asthma symptoms at age 18. The project is funded by the American Asthma Foundation and will involve participants being invited to the Clinical Research Facility at Guy's Hospital providing buccal, nasal epithelial, and blood samples. They will also be asked to complete a respiratory test that will assess their lung function and complete a skin allergy test. The study will last approximately 1 year with each assessment visit lasting up to 3 hours.
REC name
London - Fulham Research Ethics Committee
REC reference
15/LO/0155
Date of REC Opinion
21 Jan 2015
REC opinion
Favourable Opinion