A comparison of mycobiome of sputum with dust from patients’ homes
Research type
Research Study
Full title
A comparison of the mycobiomes of sputum from patients with chronic pulmonary aspergillosis and dust from their homes
IRAS ID
222203
Contact name
Malcolm Richardson
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
0 years, 9 months, 20 days
Research summary
Azole antifungal resistance has been described in both clinical and environmental isolates of the allergenic and pathogenic mould Aspergillus fumigatus. The UK National Aspergillosis Centre is a referral centre for patients with chronic pulmonary aspergillosis. Many of these patients fail treatment due to the acquire of antifungal resistance. There is concern that environmental isolates have acquired resistance due to various mutations and exposure to azole drugs used in agriculture to combat plant pathogens. Very little work has been carried out on the level of azole resistance in Aspergillus found in the indoor environment, that is, the patients’ homes. This project will focus on the diversity of environmental and pathogenic moulds in settled dust and compared with the diversity of environmental and allergenic moulds in pre-existing sputum samples from these patients. The mycobiome of pathogenic fungi in dust and sputum will be studied and described.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
17/YH/0418
Date of REC Opinion
6 Dec 2017
REC opinion
Favourable Opinion