A comparison of gait between Pompe patients and healthy individuals
Research type
Research Study
Full title
A comparison of gait patterns between late on-set Pompe disease and age-matched healthy individuals: Does late on-set Pompe disease have a typical gait pattern?
IRAS ID
121829
Contact name
Edward J Silk
Contact email
Research summary
The study is a non interventional correlation study in design. Two groups n=40(late on-set Pompe disease and normal healthy individuals. Each group will have their gait patterns assessed by instrumented gait analysis. The aim of the study is to identify a typical patterns of gait within and between the two groups.
The participants for the late on-set Pompe disease group will be recruited from the Mark Holland metabolic Unit at the Salford Royal NHS Foundation Trust. The healthy individuals will be recruited from across the normal population.
Inclusion criteria will depend on factors of either being genetically or enzymatically diagnosed with late on-set Pompe disease and being able to walk unaided for a distance of 50-550 meters in a six minute walk test. Healthy individuals who have a diagnosis of a serious musculoskeletal or neuromusclar condition will be excluded from the study. Prior to the data collection written consent and screening of the medical history will be obtained to ensure all inclusion and exclusion criteria are met. At this point participants will be formally accepted into the study.
Both groups will receive instrumented gait analysis at the University of Salford. Participants will have to walk a distance of 10 meters in straight line, no more than 10 times. Adequate rest periods will be encouraged between each recorded walk. The kinematic analysis will analyse changes in shoulder heights, pelvic translation from midline, knee angle at ground impact and speed of gait. During the instrumented gait analysis both groups will be monitored for fatigue or breathlessness using the Borg scale of exertion.
Analysis of the kinematic data will look for potential gait patterns within the late on-set Pompe disease group and potential differences in gait patterns when compared against normal, age and sex matched individuals.REC name
London - Queen Square Research Ethics Committee
REC reference
13/LO/1759
Date of REC Opinion
18 Dec 2013
REC opinion
Further Information Favourable Opinion