A comparison of body composition techniques in COPD patients
Research type
Research Study
Full title
A comparison between BIA, BIS, D2O, pQCT and DXA along with grip test to assess level of agreement between different body composition markers in COPD patients
IRAS ID
181442
Contact name
T.M. Wilkinson
Contact email
Sponsor organisation
R&D Department, University Hospital Southampton NHS Foundation Trust
Duration of Study in the UK
0 years, 5 months, 1 days
Research summary
Body composition (amount and proportion of lean and fat mass) is one of the markers of nutritional status which can be used to monitor disease progression. It has been demonstrated that as health deteriorates and body composition worsens, the ability to recover from acute illness also deteriorates and risk of mortality rises. Chronic obstructive pulmonary disease (COPD) is a disease of lungs characterized by persistent airflow limitation which is not fully reversible. Many COPD patients lose weight and muscle mass, which may have an effect on disease progression.
Different body composition markers can be used in the clinical setting. Dual energy X-Ray absorptiometry (DXA) is commonly used as a standard for body composition in clinical settings but cannot be used routinely in clinic to monitor disease progression for all COPD patients. There is a need to identify simple and reliable body composition markers that meet the needs of clinical setting to reliably characterise body composition in COPD patients. Therefore a comparison of different body composition markers is required.
On a single occasion participants (COPD patients with no infection) will be asked to attend a visit at University Hospital Southampton NHS Foundation Trust for a maximum of 5 hours. In the first place a medical review will be performed to establish disease status and identify possible medications or conditions that could affect any further measurements. Then anthropometric measurements (height, weight, limb lengths and girths, and triceps skinfold) will be performed, followed by lung function test to assess disease severity. After that a block of body composition measurements will be performed (BIA, BIS, D2O, pQCT and DXA) together with an assessment of grip strength.
Results will allow to compare body composition techniques and elucidate if any of used techniques meet the needs of clinical setting to monitor body composition in COPD.REC name
London - Bromley Research Ethics Committee
REC reference
15/LO/1233
Date of REC Opinion
12 Aug 2015
REC opinion
Further Information Favourable Opinion