A CFit Study: Acute Exercise
Research type
Research Study
Full title
A CFit Study: To what extent does a single session of exercise training influence measures of inflammation, oxidative stress, nitric oxide bioavailability, microvascular endothelial function and dysglycaemia in patients with cystic fibrosis?
IRAS ID
229686
Contact name
Zoe Saynor
Contact email
Sponsor organisation
University Of Portsmouth
Duration of Study in the UK
0 years, 10 months, 1 days
Research summary
A great medical success is the increase in the life expectancy associated with cystic fibrosis (CF). However, this success has led to a new era of research aiming to maximise the quality of life (QoL) of the aging CF population. Over recent decades, exercise training has become an integral part of CF management by improving ones aerobic fitness and QoL. However, the effects exercise training has upon other aspects of the disease, e.g. diabetes-related health and blood vessel function, remains largely unknown.
The increased survival age associated with CF means the non-respiratory consequences are becoming increasingly prevalent and clinically important. For example, CF-related diabetes (CFRD) is one of the most common non-respiratory consequence of CF, and is associated with patients having a poorer lung function and nutritional state, which ultimately leads to a worsened prognosis. Despite the efficacy of exercise training to manage diabetes-related outcomes in other populations (e.g. type 2 diabetes mellitus) only a single study has investigated its efficacy in patients with CF, whereby authors reported various encouraging findings (e.g. an improved glucose control and insulin sensitivity).
The present study aims to build on previous trials by comparing the therapeutic effects of a single session of high-intensity interval exercise (HIIE) and moderate intensity exercise (MIE) upon the various markers of diabetes-related health and blood vessel function. Additionally, the present study will investigate the mechanisms of such action by quantifying various measures of inflammation, oxidative stress and nitric oxide bioavailability.
The present study supports the top 10 research priorities set by the CF Trust, by further investigating the potential for exercise training to prevent/manage multiple aspects of CF, including diabetes-related outcomes.
REC name
South Central - Berkshire B Research Ethics Committee
REC reference
17/SC/0334
Date of REC Opinion
24 Jul 2017
REC opinion
Further Information Favourable Opinion